Junin virus infection has a mortality rate between 20 and 30%.
Argentinian mammarenavirus, better known as the Junin virus or Junín virus (JUNV), is an arenavirus that causes Argentine hemorrhagic fever (AHF).
The virus took its original name from the city of Junín, around which the first cases of infection were reported, in 1958.
Since the discovery of Argentinian mammarenavirus in 1958, the geographical distribution of the pathogen, although still confined to Argentina, has expanded. At the time of discovery, Argentinian mammarenavirus was confined to an area of around 15,000 km2. At the beginning of 2000, the region with reported cases grew to around 150,000 km2.
The toolbox for this virus is currently in development. Please contact us via info@virusbankplatform.be for more information.
import { encodeTool } from '/_js/functions.js'
FA = FileAttachment
// Load the toolbox
families = await FA("/families.json").json()
_toolbox = await FileAttachment("/toolbox/toolbox.json").json()
toolbox = _toolbox.map( tool => encodeTool(tool) )
// console.log(toolbox)
addEncodedTools = (virus) => {
return ({ ... virus, tools: toolbox.flatMap( tool => virus[tool.encoded] ? tool.id : []) })
}
// Load all Newick tree file and create a dictionary `family -> tree`
nwks = await Promise.all(
families.map(async (family) => {
let tree = await FA("/"+ family + "/tree.newick").text()
return ({ family: family, nwk: tree })
}))
nwksAsMap = Object.fromEntries(nwks.map( el => [el.family, el.nwk] ))
// console.log(nwks)
// Load annotations for viruses for each family
_annotations = await Promise.all(
families.map( async (family) => {
let xls = await FA("/"+ family + "/family.xlsx").xlsx()
let _annotations = xls.sheet(0, { headers: true, range: ":L" })
let _trimmed = _annotations.map( virus => {
let trimmed = {}
Object.keys(virus).forEach( key => {
trimmed[key] = virus[key].trim()
})
return trimmed
})
return _trimmed.map( virus => ({... virus, family: family }) )
}))
// console.log(_annotations)
// Add tools information, just the list of tools ids
annotations = _annotations
.flat()
.map( virus => addEncodedTools(virus) )familyAnnotations = annotations
.filter(virus => virus.family == virusFamily)
function virusInfo(_family, _virus) {
const info =
familyAnnotations.filter(row => row.abbreviation == _virus && row.family == _family)
return info[0]
}
// Handle grouped viruses by extending the model with isGroup: false/true
addGrouped = (virus) => {
const isGroup = (typeof virus.group_abbreviation !== "undefined") && (virus.group_abbreviation !== "")
const virus_pointer = (isGroup) ? virus.group_abbreviation : virus.abbreviation
return (
{ ... virus,
isGroup: isGroup,
virusPointer: virus_pointer,
resVirusId: (isGroup) ? virus.group_abbreviation : virus.abbreviation,
resAbbreviation: (isGroup) ? virus.group_abbreviation : virus.abbreviation,
resVirusName: (isGroup) ? virus.group_virus_name : virus.virus_name
}
)
}
// Create a list of all viruses of interest in the Excel file
// Add group information early on
annotatedViruses =
familyAnnotations
.filter(virus => virus.virus_of_interest == "Yes")
.map(virus => addGrouped(virus))
// Create a sublist of viruses with toolbox
// Take into account groups by selecting unique entries
toolboxAnnotatedViruses =
annotatedViruses
.filter(virus => virus.availability_in_toolbox == "Yes")
.filter((value, index, self) => {
return self.findIndex(v => v.resAbbreviation === value.resAbbreviation) === index;
})
// Derive a virus object from the ID
// The ID can be either a virus_id (from the ictv tree) or a group_abbreviation
virusIdToVirus = (virus_id) => {
// lookup the virus_id in the full list of viruses
const fullList =
annotatedViruses
.filter(v => v.virus_id.replace(/^'+|'+$/g, '') == virus_id || v.abbreviation == virus_id)
//.filter(v => v.virus_id == virus_id || v.abbreviation == virus_id)
// lookup the abbreviation for the group
const groupList =
toolboxAnnotatedViruses
.filter(v => v.group_abbreviation == virus_id)
if (fullList.length > 0) {
return fullList[0]
}
if (groupList.length > 0) {
return groupList[0]
}
}
// Return all matches for a virus ID
virusIdToViruses = (virus_id) => {
// lookup the virus_id in the full list of viruses
const single_virus =
annotatedViruses
.filter(v => v.virus_id.replace(/^'+|'+$/g, '') == virus_id || v.abbreviation == virus_id)
[0]
if (single_virus.isGroup) {
return annotatedViruses
.filter(v => v.group_abbreviation == single_virus.group_abbreviation)
} else {
return [ single_virus ]
}
}
function renderVirusToolbox(family, virus_id) {
// First extract the virus object from the ID or abbreviation
// This takes into account the groups
const virus = virusIdToVirus(virus_id)
if (typeof virus.tools !== "undefined" && virus.tools.length > 0) {
return html`
${toolbox.filter(tool => virus.tools.includes(tool.id) ).map(tool =>
html`
<h2 id="${tool.id}-section">${tool.name}</h2>
<div class="container grid">
<div class="g-col-12 g-col-md-3 toolbox one-tool" style="text-align:center;">
<div id="toolbox-contents" class="tool-container">
<a href="/toolbox/index.html#${tool.id}-section">
<div class="tool-wrapper">
<div id="${tool.id}" class="tool">
<div class="tool-tooltip-text">${tool.name}</div>
${tool.icon.map( i =>
html`<img class="tool-icon" height="${(tool.icon.length > 1) ? 150/tool.icon.length : 100}%" src="${i}"/>`
)}
</div>
</div>
</a>
</div>
</div>
<div class="g-col-12 g-col-md-9">
<p>${tool.description}</p>
</div>
<div class="g-col-1" style="text-align:center;">
</div>
</div>
<div class="col-xs-12" style="height:20px;"></div>
`
)}
`
}
else {
return html`
<p> </p>
`
}
}